Curated yeast data for mathematical modelingYCMDB collects, annotates and categorizes published data on yeast physiology along with its experimental context to provide a quantitative resource for cellular modelling. homepage
semanticSBML is collection of online services within the semanticSBML project.SemanticSBML provides methods to process biochemical network models in SBML format and the semantic annotations therein. homepage
Scopes - Meta Path Online Calculation of the synthesizing capacity of metabolic networks when provided with specified external resources For a given network and predefined external resources (seed metabolites), the algorithm calculates those chemical compounds which the network is in principle able to produce. This set of products is called the scope of the seed and characterizes the biosynthetic capacity of the network. Scopes - MetaPath Online
SBtab is a set of conventions for data tables, facilitating data exchange in Systems Biology. Its aim is to simplify data processing by a standardized syntax and names. This includes, among other things, prescriptions for column names, semantic annotations, and physical units. On our website, we also offer tools for the processing of SBtab files: Their syntax can be validated online and SBtab files can be converted to SBML files (and vice versa). homepage
SBOS (Systems Biology Operational Software) is a Linux live DVD designed to fit the needs of systems biologists. It features a collection of up-to-date free software tools and kinetic models installed in a Linux environment. SB.OS is based on the popular Linux distribution Ubuntu 20.04 and ready to use for all non-commercial purposes. homepage
The complexity of cellular networks is an outstanding challenge for documentation, visualisation and mathematical modeling. In this project, we develop a new way to describe these networks that minimizes the combinatorial complexity and allows an automatic visualisation and export of mathematical (ODE/rulebased) models. The development has been driven in collaboration with the Systems Biology Institute in Tokyo and partners at Linköping University and the University of Gothenburg. homepage
Plant-Phenological Online Database offers access to plant-phenological observations in Central Europe mainly Germany, from about 9000 stations, covering 130 years (1880-2009), comprising over 16 millions observations.The PPODB offers a unique data source, where, for the first time, plant-phenological observations from 129 years are brought together in one consistent database. Moreover, sophisticated outlier detection methods and quality checks are applied. homepage
Parameter balancing is a method to determine consistent parameter sets for kinetic metabolic models. Experimentally measured values, when directly inserted into a model, are likely to yield incomplete and inconsistent parameter sets. Balanced parameter sets, which are complete and consistent, are computed from kinetic constants and other data collected from experiments or the literature, based on constraints between biochemical quantities and assumptions about typical ranges, represented by prior values and bounds. On our website, users can employ an online interface of the parameter balancing tool. This requires mainly a metabolic model in either the SBML or the SBtab format. homepage
Biological network layout and visualization biographer is a biological network layout and visualization tool which has been developed at the Theoretical Biophysics Group in Berlin as part of the Google Summer of Code 2011. homepage
In Systems Biology models are created in various formats. So far only few formats (like SBML) allow the annotation of the biological context of a model. This service will help you to link your model to biological web resources by creating a CSV file containing MIRIAM annotations. homepage
Gabriele Schreiber, Facundo Rueda, Florian Renner, Asya Fatima Polat, Philipp Lorenz and Edda Klipp. Expression Dynamics and Genetic Compensation of Cell Cycle Paralogues in Saccharomyces cerevisiae.. Cells 14, March 2025. URL, DOI
Stephan O Adler, Anastasia Kitashova, Ana Bulović, Thomas Nägele and Edda Klipp. Plant cold acclimation and its impact on sensitivity of carbohydrate metabolism.. NPJ systems biology and applications 11:28, March 2025. URL, DOI
Pattarawan Intasian, Chalermroj Sutthaphirom, Oliver Bodeit, Duangthip Trisrivirat, Ninlapan Kimprasoot, Juthamas Jaroensuk, Barbara Bakker, Edda Klipp and Pimchai Chaiyen. Enhancement of essential cofactors for in vivo biocatalysis.. Faraday discussions, June 2024. URL, DOI