Parameter balancing is a method to determine consistent parameter sets for kinetic metabolic models. Experimentally measured values, when directly inserted into a model, are likely to yield incomplete and inconsistent parameter sets. Balanced parameter sets, which are complete and consistent, are computed from kinetic constants and other data collected from experiments or the literature, based on constraints between biochemical quantities and assumptions about typical ranges, represented by prior values and bounds. On our website, users can employ an online interface of the parameter balancing tool. This requires mainly a metabolic model in either the SBML or the SBtab format.
 |
 |
